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Front Pharmacol 10:1295 Chung HY, Kim DH, Lee EK, Chung KW, Chung S, Lee B, Yu BP (2019) Redefining chronic inflammation in aging and age-related diseases: proposal of the senoinflammation concept

When patients with JakobCreutzfeldt disease underwent PET imaging with [ 11 C] d-l-deprenyl and [ 18 F]fluorodeoxyglucose ([ 18 F]FDG), increased astrogliosis and decreased cerebral glucose metabolism were observed in the frontal, occipital and parietal cortices and cerebellum 351,352

Reports also show that intravenous administration of PACAP-38 can elicit a migraine-like attack in patients (Schytz et al., 2009) and cause sustained meningeal vasodilation and migraine-like photophobia in mice (Markovics et al., 2012)

Dosing Protocols That Work TB-500 Protocol: Loading phase: 5-10mg weekly for 4-6 weeks (divided into 2-3 doses) Maintenance: 2-5mg monthly Typical vial: 5mg Cost: 40-60 per vial BPC-157 Protocol: Standard dose: 250-500mcg twice daily No loading phase needed Typical vial: 5mg Cost: 30-50 per vial Combination Protocol: TB-500: 5mg weekly (2.5mg twice weekly) BPC-157: 250mcg twice daily Duration: 4-8 weeks Total cost: 400-600 for full protocol The Injection Reality Both require subcutaneous injection, but experiences differ: TB-500 is typically twice weekly, larger volume, and can inject anywhere (works systemically)