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Pathogenic loss-of-function variants in SLC52A2 or SLC52A3 abrogate membrane uptake of riboflavin, precipitating secondary FMN/FAD depletion in metabolically demanding neurons and glia (13, 14)

However, our meta-analysis revealed that this effect peaked at 18 weeks and subsequently declined, with no significant benefits sustained during the 18- to 36-week treatment period