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The outstanding progress accomplished in the last years allows to assert that, even though the pathways implicated in the induction/execution of apoptosis have remained largely unaltered, many new redox-dependent processes have been added and we suggest the reading of several reviews on this subject (Anathy et al., 2012

doi: 10.3390/ijms262411872

Consequently, dose reduction or treatment withdrawal is often necessary, as current clinical management of the adverse effects is limited to pain control and is not able to prevent or reverse the underlying neuropathy (Avan et al