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For the uninitiated, prepare yourself

In our prior work, we delineated an interoceptive brain system, which includes the insula, ACC, somatosensory cortex, thalamus, and PAG (all implicated in CIPN), as well as other regions largely delineated by a DMN-like network and a sensory-oriented network (Kleckner et al., 2017)

It reflects the consensus of this guideline working group and is supported by several publications (see Hberle et al

A common example is the amalgam tattoo, which occurs when small particles from dental amalgam fillings become accidentally embedded in the soft tissues of the mouth during dental procedures (Figure 8)