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MECHANISM CATEGORIES RESEARCH CONDITIONS SAFETY Side effects Limited human safety data Animal toxicology shows wide therapeutic window Injection-site reactions reported anecdotally Known interactions Anticoagulants (theoretical, due to angiogenic activity unstudied) Contraindications Active malignancy (theoretical, due to angiogenic mechanism) Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Placed on FDA Category 2 of the 503A bulks list (September 2023 update), barring compounding pharmacies from preparing it under section 503A

Multidrug-tolerant mutant Salmonella enter a near-dormant state protected from immune-mediated genotoxic damages

Glutathione encourages its breakdown by acting as a substrate of the enzyme formaldehyde dehydrogenase

doi: 10.1016/j.heliyon.2023.e18991 7 AndersH