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However, persistent pale clay-coloured stools, black tarry stools, blood in stools, or colour changes accompanied by jaundice, severe pain, or unexplained weight loss require medical assessment

[12] Very high cumulative exposure over months may encourage calcium deposition in soft tissues such as the renal parenchyma or coronary arteries, an outcome implicated in observational studies linking supra-physiological 25-hydroxyvitamin D levels with vascular calcification and heightened fracture risk in frail elders

This is when adhesions begin to build up

Nearly a 15% reduction in body weight from a single weekly injection combined with lifestyle modifications