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Impact of abnormal mechanical stress on chondrocyte death in osteoarthritis

*Correspondence: Kangrong Lu, [email protected] Wang, [email protected] These authors have contributed equally to this work and share first authorship This article was submitted to Brain Disease Mechanisms, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The isoenzyme of glutathione peroxidase GPx1 that is most active towards H 2 O 2 is localized mostly in the cytoplasm, but a small amount is also present in the mitochondrial matrix [42]