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Research from Oxford University demonstrates that mepolizumab not only reduces eosinophil counts but reverses the primed hyperactive state these cells develop in severe asthma. This treatment is specifically designed for patients with severe eosinophilic asthma , defined as having blood eosinophil levels of 150 cells per microliter or higher despite using high-dose inhaled corticosteroids plus additional controllers

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Decreased circulating SHBG levels have been consistently reported in individuals with metabolic and inflammatory disorders [24]