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Ferroptosis in Parkinsons disease: molecular mechanisms and therapeutic potential

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Groups of 10 male Wistar rats were exposed to acetaldehyde, for 6 h/day, 5 days/week, for 4 weeks, in three different patterns: (a) as a continuous daily exposure of 6 h to 0, 270, or 900 mg/m 3 (0, 150, or 500 ppm), (b) as two daily exposures of 3 h to similar concentrations with an intervening 1.5-h period with no exposure, or (c) as two daily 3-h periods of exposure to similar concentrations with an intervening 1.5-h period with eight short (5-min) peaks of 6 times the basic concentration, resulting in time-weighted average concentrations of 0, 255, or 1050 mg/m 3 , respectively