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Most commercially available supplements in the UK provide doses ranging from 500 mg to 2,000 mg per day, typically taken in one or two divided doses

There are a number of other disease variants within this continuum, however, it beyond the scope of this article to cover in more detail

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Molecular mechanisms by which these phytochemicals might influence VDR signaling include modulating VDR expression and stability, enhancing co-activator recruitment, and crossing with other signaling pathways like PI3K/Akt, AMPK, and Nrf2 pathways (Cuenca-Mic and Aceves, 2020)