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J Rheumatol 33:20152019 Dieud P, Bouaziz M, Guedj M, Riemekasten G, Air P, Mller M, Cusi D, Matucci-Cerinic M, Melchers I, Koenig W, Salvi E, Wichmann HE, Cuomo G, Hachulla E, Diot E, Hunzelmann N, Caramaschi P, Mouthon L, Riccieri V, Distler J, Tarner I, Avouac J, Meyer O, Kahan A, Chiocchia G, Boileau C, Allanore Y (2011) Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe/532Ser haplotype

It actually does not have a direct effect on the cell

They help regulate: Appetite Blood sugar Digestion Immune activity Inflammation Growth and repair Sexual function Blood vessel function Brain signaling Sleep and circadian rhythm Hormonal communication This is why the phrase peptide therapy covers such a broad range of treatments

However, they diminished over time