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Description

Consequently, this phenomenon holds significant therapeutic relevance (86)

HDAC6 inhibition effectively reverses chemotherapy-induced peripheral neuropathy

The treatment enhanced the PI3K (phosphoinositide 3 kinase)/Akt pathway

FAAH-1 is responsible for the degradation of anandamide to arachidonate and ethanolamine, while MAGL is responsible for the degradation of 2-AG to arachidonate and glycerol (Simard et al., 2022)