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b) oil-soluble OSCs reported to be more toxic in comparison to water-soluble OSCs and c) toxicity associated with OSCs becomes much less harmful over time

Furthermore, ferulic acid treatment in a mouse model of neuroinhibition reduces p-JNK, p-NFB in glial cells of the mouse hippocampus and activates mitochondrial apoptotic molecules (Bax, cytochrome c, caspase-3, and PARP-1) in small/medium glial cells to induce anti-inflammatory effects by interfering with the TLR4/MD2 complex binding site (Nagarajan et al., 2015)

In recent years, a lot of efforts have been made in developing in vivo and ex vivo gene therapy solutions for the treatment of a wide range of diseases, from haploinsufficiency therapy and treatment of inherited metabolic diseases to immune deficiencies, blood disorders, solid tumors, and neurological disorders [46,47,48,49,50,51,52,53,54,55,56,57]

doi: 10.3390/cells10123548 130 ZhangH