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The combination of viral persistence, microbiome dysbiosis, and localized inflammation inevitably leads to the degradation of the intestinal barrier, a condition clinically known as intestinal hyperpermeability, or "leaky gut." The intestinal lining is only one cell thick, and these cells are glued together by complex protein structures called tight junctions

Phosphoproteomic profiling revealed cytoskeletal regulation as a major process affected by curcumin, with CLASP2 emerging as a critical target