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In most studies, prophylactic therapy has been continued for 3 to 12 months following discontinuation of immunosuppressive therapy,[45,55,56] and reactivation has rarely been reported greater than 12 months following cessation of chemotherapy.[57,58] The AASLD and AGA recommend continuing antiviral therapy for at least 6 months after completion of most immunosuppressive therapy.[3,8,51] This recommendation is extended to 12 months for patients receiving B-cell-depleting agents.[3,8,51] Conversely, the ASCO recommends antiviral prophylaxis for at least 12 months following completion of all chemotherapy.[52] Monitoring Low-Risk Patients Off Antiviral Therapy Patients on immunomodulatory therapy who are at low risk for HBV reactivation and not initiated on prophylactic antivirals should be monitored routinely for HBV reactivation