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8A), subsequently, increased activity of POX and CAT (Fig

Targeting glutamine metabolism transporter inhibitors Gln metabolism has received increasing attention in the process of material transport and energy metabolism in cancer cells, and increased Gln catabolism in cancer cells has been associated with increased expression of Gln transporter proteins

ROS then interacts with lipids in the cell membranes causing cellular death

Specifically, the Akt signal pathway directly acts on FoxO3a to reduce its expression, further inhibiting production of autophagy marker LC3B on the collagen matrix, leading to excessive collagen accumulation (Im et al., 2015)