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Additionally, tyrosines play an important role in aSyn-vesicle binding while nitration impairs this interaction (making the charge more negative at the N-terminal domain, or causing a conformational change when the C-terminal domain is nitrated) thereby increasing the amount of aSyn in a random coil or beta-sheet conformation and thus shifting equilibrium toward oligomer formation 105,106,109

This Research Topic aims to highlight recent advancements and challenges in MS-based adductomics within biological matrices, and further adductomic approaches to the study of the exposome in health and disease

Collectively, HDL has multiple biological mechanisms that inhibit thrombus formation, and thus, contribute to HDLs anti-atherogenic properties