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Dual regulation of heat-shock transcription factor (HSF) activation and DNA-binding activity by H2O2: role of thioredoxin

For example, direct GAPDH inhibitors 115 selectively kill highly glycolytic cancer cells, while an engineered lactate oxidase/catalase enzyme was shown to lower NADH levels and restore GAPDH activity, glycolytic ATP production, and proliferation in cells with impaired NAD regeneration 116

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