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Description

Loss of NCOA4 substantially decreases ferroptosis susceptibility, reducing cell death by approximately 62% (Savo and Dill, 2019)

& Ovadia, H

In the absence of reduced glutathione (e.g., due to G6PD deficiency), RBCs become susceptible to oxidative stress that can damage erythrocyte membranes, resulting in intravascular and extravascular hemolysis