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Hosnedlova et al., 2018

In general, a platform or oral first line DMT (fl-DMT) was offered unless any of the following circumstances occurred: (i) two clinical attacks in a year, (ii) a clinical attack and/or a new gadolinium-enhanced lesion (GEL) within a year, or (iii) a disabling clinical attack with residual EDSS of at least 2 points in the pyramidal system

The Pineal Gland: a neurochemical transducer: chemical signals from nerves regulate synthesis of melatonin and convey information about internal clocks

For IVDs injected with DFbs, the IVD height improved when the disc was under pressure, with biomechanical effects of bearing pressure and pressure curves similar to those observed for sham IVDs (Fig