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This supports our observation that the presence of positive/polar charged residues at this position interacting with negatively charged phosphorylation sites in the R-domain is important for proper functioning of this family of transporters (Supplementary Fig

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This section will conceptually elaborate on the common vulnerability axes in GI tumors related to lipid, amino acid, metal ion, and energy metabolism, as well as their antioxidant defense systems, laying the theoretical groundwork for the subsequent in-depth discussion of specific molecular mechanisms in each cancer type