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[Abstract] Cancer Biol Ther

Uncontrolled production of ROS and cytokines results in oxidative stress and inflammation

In fact, GSH is present in some mammalian cells at concentrations near to 10 millimolar (Cooper and Kristal, 1997) and MeHg has been reported to cause oxidative damage in cultured neuronal cells when added to the culture medium at concentrations as low as 300 nanomolar (Farina et al., 2009)

Interestingly, recent studies indicate that in the setting of ATII-induced hypertension, a downregulation of the dihydrofolate reductase was observed, which was accompanied by decreased vascular BH 4 levels and an uncoupled eNOS, 91 implicating a potential role of this salvage pathway in the development of hypertension