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In the present study, we tested the hypothesis that NRF2 activation via dietary supplementation with Protandim would prevent salt-induced oxidative stress and endothelial dysfunction and down-regulation of the expression of two key vascular antioxidant enzymes [Cu/Zn SOD (SOD1) and Mn SOD (SOD2)] in two established animal models of pressure-independent vascular dysfunction induced by high salt diet (Sprague-Dawley rats and Syrian hamsters)

Monitoring helps identify trends rather than relying on a single reading

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The tissue microarrays (TMAs) were constructed as described previously ( H -score, a combination of the proportion of positive cells and the staining intensity, was applied to assess the results of IHC