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In this method, Ag + ions oxidize o-phenylenediamine (OPD) to produce OxOPD, causing a change in the FRET signal between 562 and 442 nm

despite only modest gains in intrinsic potency, it achieves effective concentrations in vivo and delays tumor growth in xenograft models (12)

The absence of tissue growth effects also means AOD-9604 avoids many common side effects of growth hormone therapy including joint pain and swelling from connective tissue proliferation, carpal tunnel syndrome from tissue expansion, edema and fluid retention from protein synthesis and sodium retention, and concerns about growth-promoting effects in individuals with tumor history

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