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133 Additional regulators of this process include AMPK (AMP-activated protein kinase), nitric oxide (NO), SIRTs (sirtuins), TORCs (transducers of regulated CREB-binding protein), CaMK (calcium/calmodulin-dependent protein kinase), calcineurin, p38 MAPK, RIP140 (receptor-interacting protein 140), and Sin3A, which all influence mitochondrial biogenesis through the activation of PGC-1