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10.1016/s0165-0173(02)00158-3 39 FranssonR.BotrosM.NybergF.LindebergG.SandstrmA.HallbergM

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Alterations of mtDNA-CN might also represent a consequence to the accumulation of mutations in regulatory regions or genes responsible for mtDNA replication/transcription apparatus, such as DNA polymerase subunit gamma ( POLG) , Transcription Factor A, Mitochondrial ( TFAM) , p53 or Displacement- loop ( D-loop) (Lin et al

GHK-Cu has been shown to suppress NF-B inflammatory pathways and reduce pro-inflammatory cytokines, the biological signals that keep that cycle running