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Similar content being viewed by others Introduction Psoriasis vulgaris is a chronic immune-mediated inflammatory skin disease characterized by scaly skin plaques caused by keratinocyte hyperproliferation and immune cell infiltration 1

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The angiopep-2 peptide that binds to low-density lipoprotein receptor-related protein-1 (LRP-1) was conjugated to paclitaxel via a succinyl group (named ANG1005) and applied to the treatment of glioma and metastatic breast cancer 82

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Particularly, they found a positive relation between serum D-lactate (a marker of increased intestinal permeability) and markers of hepatocytes necrosis, cholestasis, and triglycerides metabolism [47]

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