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p53, as an effective oncogene, promotes ferroptosis mainly through the canonical and non-canonical pathways (Dixon et al., 2012)

3.3.4 AIM2 inflammasome pathway Absent in melanoma-2 (AIM2) inflammasome is a member of the innate immune sensor, which can detect double-stranded DNA (dsDNA), including mtDNA, in the cytoplasm independent of sequence

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However, challenges remain with AHR agonists, particularly because increased CYP enzyme activity induced by AHR activation can affect their absorption and entry into the circulatory system [10]