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Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

Consequently, we deemed it essential to consolidate the acquired knowledge on Epitalon, not merely as a summary, but also to facilitate the planning of future studies on this interesting peptide

169 Molecular mediators that drive organ crosstalk Interorgan crosstalk among the kidney, heart, brain, adipose tissue, liver, skeletal muscle, pancreas, and intestine plays a pivotal role in the development of insulin resistance and -cell dysfunction, which are central to the progression of diabetic complications