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Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6

Marques PE, Amaral SS, Pires DA, Nogueira LL, Soriani FM, Lima BH, et al

The studies demonstrated the importance of not only the amino acid residue isoleucine 253 (I253) in the IgG Fc, but also of histidines (including H310 and H435), the pKa of which results in protonation/deprotonation in the endosomal pH range

Depression ranges from everyday situational depression to major depressive disorder, characterized by profound hopelessness, helplessness, and biological symptoms such as sleep disorders and anhedonia and can be mimicked by symptoms of cirrhosis like HE and delirium, necessitating careful psychiatric differential diagnoses