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Mitochondrial disease refers to a group of clinically heterogeneous disorders caused by dysfunction in the mitochondrial respiratory chain, often due to mutations in mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) that encodes mitochondrial proteins

Additionally, 15-d-PGJ 2 induces apoptosis in follicular keratinocytes, as evidenced by increased expression of the pro-apoptotic Bcl-2-associated X protein (BAX) and caspase 3, as well as decreased expression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) [181]

Older adults are more likely to be in a depleted state and may respond more dramatically to supplementation