glutathione homocysteine metabolism metabolic pathway. Homocysteine sits at the intersection New Insights into the Roles

In chronic or adjunctive settings, ongoing monitoring is recommended to avoid toxicity

Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining TUNEL staining was performed using the Colorimetric TUNEL Apoptosis Assay Kit (C1091, Beyotime, Shanghai, China)

45 Initially, patients receiving methadone must return to the clinic a minimum of six days per week for medication administration with appropriate supervision for at least the first 90 days of treatment

a non-oral method or additional barrier contraception during initiation and escalation may be advisable until more data are available