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Since we could not exclude that the reduced TLR3 activation was in part due to the reduced replication of JFH1 D1467G, we aimed to analyse TLR3 activation in stable replicon cell lines

In contrast, when two DNA double-strand breaks in two different chromosomes recombine to form one chromosome with two centromeres and two fragments of chromosomes without centromeres or telomeres, cell death is inevitable

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By integrating recent advances in molecular profiling and ferroptosis biology, this review provides a framework for leveraging ferroptosis as a tractable target in IPF and identifies novel directions for precision antifibrotic therapy