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pH-responsive nanovesicles capable of remodeling the tumor microenvironment enable activatable near-infrared-II fluorescence image-guided enhanced radiotherapy

While many synthetic polymers are bio-inert, they are frequently engineered to incorporate functional groups that allow cells to bind to and interact with the hydrogel (Peppas et al., Poly(ethylene glycol) Poly(ethylene glycol) hydrogels are a commonly used synthetic biomaterial for drug delivery (Peppas et al., To facilitate hydrogel formation, PEG can be crosslinked by two mechanisms: step-growth and chain-growth, or a combination of the two, termed mixed-mode

Co-treatment with Spirulina platensis aqueous extract (SPAE) led to a dose-dependent reduction in Keap1 expression, with the 800 mg/kg dose showing the most pronounced effect (0.80 0.05), significantly lower than both the DEX and SPAE 400 mg/kg groups (1.20 0.07)

They start as red spots that hurt when touched, but they eventually grow in size and rupture, leaking fluids