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Nevertheless, these studies mainly used disulfide-thiol exchange to deplete GSH for GPX4 inactivation, which is difficult to inactivate GPX4 completely because of the compensatory effect of the continuous synthesis of GSH

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Transcriptional regulation Comparison of mouse, rat, and human gene sequences indicates a conservation of the sequence and overall structure of the GPx-1 gene, with the protein coding region contained within two exons and the Sec codon in the first exon (Fig