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Lipophilic, nonpolar, and low molecular weight substances such as oxygen, carbon dioxide, and alcohol can pass through the cardiovascular cell membrane and enter the BBB through a cross-cellular pathway[33]

The N-terminal acetylation of Semax has been suggested to result in enhanced resistance to hydrolysis and may also increase the peptides ability to reach the binding sites where the molecule exerts its effects [4]

[DOI] [PubMed] [Google Scholar] 14.Lau SJ, Sarkar B

Its gastric stability is remarkable: it survives the stomach's pH of 1-2 without being degraded, opening the possibility of oral administration in certain preclinical protocols