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Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links

3 Therapeutic potential of GA for the pathogenetic basis of ASCVD Hyperlipidemia, arterial stiffening, and AS collectively constitute the core pathological basis of ASCVD (Dutta et al., 2024

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Here, we report two cryo-EM structures of Ycf1 at 3.4 and 4.0 resolution in inward-facing open conformations that capture previously unobserved ordered states of the intrinsically disordered regulatory domain (R-domain)