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[46] However, Alberti et al

4 First, it can be metabolized through the glycine cleavage system, a complex enzyme system that conducts the reversible reaction at the last step of producing glycine from serine

For primary analysis, we excluded the studies among healthy populations and overweight individuals

In addition, more lipophilic drugs will tend to pass not only through the BBB, but also to other organs, which consequently results in a reduced availability of drugs to enter the brain (27)