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Elevated levels of adenosine in certain brain regions, such as the cortex and basal forebrain, have been associated with prolonged wakefulness, while lower levels are observed during sleep recovery periods

Cross-cancer comparisons reveal that although the SSP serves conserved functions in sustaining one-carbon unit supply and mediating therapeutic resistance across cancer types, the remarkable heterogeneity of its upstream regulatory mechanismsincluding Kras/FGFR3 mutations, MYC-mediated stemness maintenance, and m6A epigenetic modificationsdictates that therapeutic strategies must be precisely tailored

Finnell JE, Lombard CM, Padi AR, Moffitt CM, Wilson LB, Wood CS, et al

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