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Sena and Chandel, 2012)

Clinical Significance of High Homocysteine Levels Figure 7: Decoding Homocysteines Role in Health Homocysteine (Hcy) is a useful marker for detecting health issues

On the other hand, majority of IGF-I actions are mediated through the union of IGF-I to its putative receptor, IGF-IR, a tyrosine kinase that is one of the most potent natural activators of Akt pathway, involving among others: mTOR, MAPK, GSK3, FOXO, HDM2, Grb2 and Shc systems, all of them closely related with cell survival, growth and proliferation[1517]

Amentoflavone initiates ferroptosis by promoting autophagy via AMPK/mTOR signaling, while autophagy inhibitor BafA1 or depletion of ATG7 compromises this effect[109]