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Konopaske GT, Dorph-Petersen K-A, Sweet RA, Pierri JN, Zhang W, Sampson AR, et al

Safety and toxicity concerns present major challenges for the global ADC market, as potent cytotoxic agents can lead to severe side effects, including blood disorders and organ-specific toxicities

4.2 Circadian disruptiondriven metabolic insufficiency and Treg functional decline Circadian rhythms, the intrinsic 24-hour biological cycles, profoundly influence immune system function, including the regulation of Tregs, which are essential in maintaining immune tolerance and preventing autoimmunity such as uveitis

reported that solid-state cuprous compoundsincluding Cu 2 O, Cu 2 S, CuI, and CuClexhibit significantly greater antiviral activity than either silver or their cupric analogues