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Tan AC, Ashley DM, Lpez GY, Malinzak M, Friedman HS, Khasraw M

A retrospective review of 69 patients administered oxaliplatin concluded that calcium channel blockers reduce CIPN (Tatsushima et al., 2013)

The pathogenesis involves multiple factors, including (i) increased sebum production, (ii) follicular hyper-keratinization and corneocyte hyper-cohesiveness, (iii) the proliferation of the bacterium Cutibacterium acnes (formerly known as Propionibacterium acnes ), and (iv) inflammation that is neutrophil driven in early lesions and Th1/Th17 driven in established lesions