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doi: 10.1016/j.prdoa.2019.07.006 33

For example the media widely considered the RECOVERY HCQ RCT to be conclusive on efficacy, but very late treatment of late stage patients (mostly on oxygen already) with an excessive toxic dose (shown dangerous in a dose comparison RCT) provides no information on the recommended early/prophylactic treatment

10.1097/01.mco.0000247469.26414.55 180

In support of this, in colony formation assays we observed much more pronounced effects using smaller doses of each inhibitor in the representative OXPHOS high cell line SHP77 compared to the OXPHOS low cell line H196 (Supplementary Figure S10)