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4 Chemotherapy and cell death pathways modulation Cell death, a crucial aspect of the response to chemotherapy, can occur through various mechanisms, each influencing chemoresistance: during tumor progression, the balance between pro-cell death and anti-cell death regulators is shifted towards survival by various escape mechanisms ( Apoptosis, discovered in 1972, is a programmed and controlled process of cell self-destruction requiring specific cell signaling transduction (Wang et al., 2023)

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By contrast, mitochondrial biogenesis, a complex biological process essential for mitochondrial self-renewal, is primarily regulated by peroxisome proliferator-activated receptor-g coactivator-1 a

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