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The effect of Fer-1 was verified with experimentally administered ventricular Fer-1 in experiments with rats, where it was found to inhibit erastin-induced accumulation of ROS in the cytoplasm and lipids, resulting in a decrease in ROS and lower levels of ferroptosis, demonstrating that Fer-1 could appreciably slow down the onset of ferroptosis in the brain (171)

Rev Bras Bot 39:393407 Rahman ML, Sarjadi MS, Sarkar SM, Walsh DJ, Hannan JJ (2022) Poly(hydroxamic acid) resins and their applications

However, it is still sufficient to ensure rapid clearance of damaged erythrocytes and prevent their lytic cell death

Collectively, these findings suggest that ROS-induced OS plays a pivotal role in steatosis, inflammation, and apoptosis, contributing significantly to the progression of ALD