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SRS is characterized by proportional IUGR with severe SGA at birth, relative sparing of the brain with close to normal head circumference at birth, severe feeding difficulties in infancy and childhood (which in contrast to Prader-Willi syndrome does not rebound into feeding obsession later in life), postnatal growth retardation and body asymmetry

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During the recruitment appointment and subsequent follow-up appointments at six and twelve months, the clinical status and mental health of all volunteers were evaluated, peripheral blood samples were collected, 45 plasma biomarkers (cytokines, chemokines, and growth factors) were assessed, and a comprehensive investigation was conducted using neuropsychological and ophthalmological tests, PET-CT, and magnetic resonance neuroimaging