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BDNF is widely expressed in neurons, astrocytes, and microglia, among which microglia are regarded as the primary source of BDNF (162)

The proportion of subjects becoming non-self-sufficient after 12 months of follow-up, defined as those scoring 2 or lower on at least one of the ALSFRS-R items for swallowing, and/or cutting food and/or handling utensils, or walking, in subjects treated with ALCAR 3 g/day and not treated subjects

These lipids typically constitute a very small proportion ( 20 kJmol 1 68,69 ) resulting in timescales on the order of hours to weeks

As it travels through the blood, it can penetrate the brain and other organs without cellular transporters