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5.1 Nonpharmacologic approaches CR mitigates senescence-associated renal changes by activating SIRT1 and AMPK, blocking mTOR and NF-B signaling pathways, and inhibiting the activity of endothelin-1 (ET-1) (Wang et al., 2021), thereby promoting autophagy and reducing oxidative stress (Ning et al., 2013)

Janneke Balk, John Innes Centre, Norwich, UK for sharing the nramp3nramp4 double mutant with us

Most published evidence has been generated using in vitro experiments and animal models, with limited human clinical data currently available

Impurities, synthesis-related fragments, and incorrect amino acid sequences can act as catalysts, accelerating the degradation process once the peptide is reconstituted