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Matsuoka K, Nakatani Y, Yoshimura T, Akasaki T

Several studies have linked long-term use of glutathione supplements to low zinc levels, and patients consuming the nutrient orally have reported digestive distress including abdominal cramps and bloating

When the RAS protein binds to GTP in an activated state, the downstream Ras-Raf-MEK-ERK signaling pathway is abnormally activated, and excessive proliferation signals are transmitted, leading to uncontrolled cell proliferation and the development of tumors ( 3.5 Prostacyclin synthase (PTGIS) PTGIS is a member of the CYP8 family that catalyzes the conversion of prostaglandin H2 to prostacyclin I2 (PGI2) (Yu et al., 2017)

doi: 10.3389/fmicb.2015.01056 136 TyagiSLeeK-JShuklaPChaeJ-C