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Received: 13 May 2025 Revised: 04 June 2025 Accepted: 23 June 2025 Published: 27 June 2025 2025 The authors

Adults require approximately 1.5 micrograms daily (NHS guidance), with B12 found naturally in animal products

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PE-22-28: TREK-1 Channel Blockade# PE-22-28 (Gly-Val-Ser-Trp-Gly-Leu-Arg) is a synthetic 7-amino acid peptide derived from spadin, itself an endogenous peptide released by proteolytic processing of sortilin (neurotensin receptor-3)